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A compendium of biological and pharmacologically relevant ligands


Database of Protein Data Bank structures, ligands and annotated functional site residues. Accessed by PDB codes, UniProt accession numbers and keywords.

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Predicts functionally important residues based on the local evaluation of alignments between the query sequence and the structures with functional information stored in FireDB.

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The Server for Quick Alignment Reliability Evaluation is a Web-based version a the method to predict regions of reliably aligned residues in sequence alignments.

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Additional features

Ligand info

Every chemical compound in the PDB is stored with its description, the PDB structures in which it is present and the amino acids pre-calculated to be in contact with the ligand.

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The Ligand Contact Tool

LCT is a tool to calculate contacts between protein and ligand atoms. Residues are considered in contact when one of his atoms is within a user-established Angstrom distance.

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A system that deploys a range of computational methods to provide annotations of alternative splice isoforms and identify principal isoforms for vertebrate species.

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All the help and documentation on the different tools that make up Firesuit can be found in the Help section of the navigation bar or in the following link:

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FireDB and firestar tools are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Authors: Gonzalo Lopez, Alfonso Valencia & Michael L. Tress
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