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A compendium of biological and pharmacologically relevant ligands
FireDB
Database of Protein Data Bank structures, ligands and annotated functional site residues. Accessed by PDB codes, UniProt accession numbers and keywords.
Access the databaseFirestar
Predicts functionally important residues based on the local evaluation of alignments between the query sequence and the structures with functional information stored in FireDB.
Run the toolSQUARE
The Server for Quick Alignment Reliability Evaluation is a Web-based version a the method to predict regions of reliably aligned residues in sequence alignments.
Run the web serverAdditional features
Ligand info
Every chemical compound in the PDB is stored with its description, the PDB structures in which it is present and the amino acids pre-calculated to be in contact with the ligand.
Access the databaseThe Ligand Contact Tool
LCT is a tool to calculate contacts between protein and ligand atoms. Residues are considered in contact when one of his atoms is within a user-established Angstrom distance.
Run the toolAPPRIS
A system that deploys a range of computational methods to provide annotations of alternative splice isoforms and identify principal isoforms for vertebrate species.
Go to APPRIS web pageHelp:
All the help and documentation on the different tools that make up Firesuit can be found in the Help section of the navigation bar or in the following link:
License:
FireDB and firestar tools are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Authors: Gonzalo Lopez, Alfonso Valencia & Michael L. Tress
Contact mail: dcerdan@cnio.es